Compared with traditional chemotherapy and radiation therapy, immunotherapy uses the immune system to fight the tumor, with less toxic side effects and more effective treatment. Among them, immunogenic cell death can activate the human immune system through dead cell antigen to achieve immunotherapy. At present, small molecule drugs have been used in clinical treatment of immunogenic cell death, however, how to accurately control the induced immunogenic cell death in the treatment of tumor is of great significance to improve the therapeutic effect.
Recently, an ultra-precision optical manufacturing innovation team led by Academician Zhuang Songlin and Professor Zhang Dawei at the University of Shanghai for Science and Technology has regulated a wide-band gap bismuth fluoride nanomaterial into a narrow band gap sulfur-doped bismuth oxide nanomaterial through topological synthesis strategy for immunogenic cell death mediated tumor immunotherapy. The results show that sulfo-doped bismuth oxide nanomaterials have higher electron-hole separation efficiency and can produce more active oxygen species under ultrasonic stimulation. The doping of sulfur can extend its light absorption range and make it have good photothermal conversion performance at 730 nm. The released bismuth ions will react with overexpressed glutathione in the tumor microenvironment, amplifying the oxidative stress of tumor cells. Ivermectin was loaded into its mesoporous structure to further enhance the immunogenic death of tumor cells and ultimately achieve a more effective immune response.
Research diagram
The results of this paper were published in Weliy top journal Small (2023 latest IF=13.3, the first area of Materials Science, Chinese Academy of Sciences), and was selected as the internal cover paper. "Topological regulating bismuth nano-semiconductor for immunogenic cell death-mediated hyperthermia. sonocatalytic Hypertherapy, Guo-Bo Chen, M.S. and Zhijin Yang, Ph.D., are the first authors. Yuhao Li, Associate Professor, and Lulu Zheng are co-corresponding authors.
Inner cover drawing
Full text link:
https://onlinelibrary.wiley.com/doi/10.1002/smll.202304032
Inside cover link:
https://onlinelibrary.wiley.com/doi/10.1002/smll.202370402
