The University of Shanghai for Science and Technology (USST) authorized the first-level discipline of Control Science and Engineering (DCSE) to offer the master’s degree and doctoral degree in 2006 and 2016, respectively. Over the past decade, the discipline has established a competitive and high-level faculty, including more than 20 doctoral supervisors and 10 national/provincial talents, such as members of the European Academy of Science, Germany Academy of Science and Engineering, as well as New Century Innovative Talent Program of Ministry of Education of China. The DCSE has jointly set up the Industrial Process Automation of National Engineering Research Center with the Shanghai Institute of Process Automation & Instrumentation Co., Ltd, and has also built other national/provincial scientific research platforms, such as the Shanghai Key Laboratory of Intelligent Control of Optoelectronic Systems and Collaborative Innovation Center for Intelligent Instrument and Industrial Automation. Relying on the School of Optical-Electrical and Computer Engineering, the DCSE focuses on national key strategies, accommodates the demand of the industry, and pays special attention to interdisciplinary integration. Following this trend, the DCSE has formed some stable research directions involving control theory & engineering of complex industrial systems, intelligent computing & networked systems, and pattern recognition & intelligent systems. It has carried out a series of cutting-edge research in the innovative fields of control and filtering of networked systems, intelligent robots, energy scheduling, man-machine interaction and affective computing, medical image processing, and industrial big data. During the recent five years, the DCSE has undertaken or cooperatively undertaken over 60 national projects such as the National Key R&D Program of the Ministry of Science and Technology, the Key Program of the National Natural Science Foundation of China, and the General Program of the National Natural Science Foundation of China. Furthermore, the DCSE has published over 200 papers in famous IEEE Transactions and Automatica, and among them, more than 20 papers have been published in IEEE Transactions on Automatic Control and Automatica, the top journals of the control community. Till now, the DCSE has won 1 first-class Science and Technology Progress Award of Wu Wenjun Artificial Intelligence and 1 first-class Natural Science Award of the Ministry of Education.